Roda E, Pezzoli A, Fusaroli P, Fabbri C, Jaboli F, Marchetto S, Azzaroli F, Mazzella G
Dipartimento di Medicina Interna e Gastroenterologia, Università degli Studi di Bologna.
Ann Ital Med Int. 1996 Oct;11 Suppl 2:48S-52S.
Cholestasis syndromes are characterized by a reflux of compounds usually excreted with bile. ATP dependent carriers and cytoskeleton proteins guarantee physiological bile flux. There are several clinical conditions in which this system is affected. Intrahepatic cholestasis is characterized by damage to hepatocytes or intrahepatic bile ducts. Primary biliary cirrhosis and primary sclerosing cholangitis represent examples of cholestatic chronic liver disease. The pathogenesis of these two conditions seems to be mediated by immunological reactions. Moreover, hepatitis viruses are able to induce cholestasis.
胆汁淤积综合征的特征是通常随胆汁排泄的化合物发生反流。ATP 依赖性载体和细胞骨架蛋白保证了生理胆汁流动。有几种临床情况会影响这个系统。肝内胆汁淤积的特征是肝细胞或肝内胆管受损。原发性胆汁性肝硬化和原发性硬化性胆管炎是胆汁淤积性慢性肝病的例子。这两种情况的发病机制似乎是由免疫反应介导的。此外，肝炎病毒能够诱发胆汁淤积。
