Siegert R, Klitzing L
Klinik für Hals-, Nasen- und Ohrenheilkunde, Medizinische Universität zu Lübeck.
HNO. 1996 Sep;44(9):497-502. doi: 10.1007/s001060050044.
The term "flow motion" stands for the phenomenon of spontaneous and autonomous rhythmic variations of the contractile state of the smooth muscles of small dermal vessels. There also have been a few observations of variations in the microcirculation of the mucosa, but they have not been evaluated in detail to date. The aims of this study were to develop a method for investigation flow motion, especially in the nasal mucosa; to compare nasal flow motion to that of other skin and mucosal areas; to evaluate the influence of normal saline solution, as well as a sympathomimetic agent and histamine on flow motion. The microcirculation of the nasal mucosa of 40 healthy volunteers was measured under standardized conditions. In a first series of investigations, the microcirculations of the forehead, lobule of the ear, nose and oral mucosa were compared. In the second series, the microcirculation of the nasal mucosa was measured with laser-Doppler flowmetry before and after provocation with 0.9% saline solution, 0.25 mg oxymetazoline hydrochloride as sympathicomimetic preparation and 0.085 mg histamine in 0.5 ml of 0.9% saline solution. Evaluation of the data included signal analysis of the microcirculatory variations using fast-Fourier transformation and its changes before and after the pharmacological stimulations. Distribution of the power spectra showed that the nasal mucosa was significantly different from that of the skin of the forehead and the ear. Oxymetazoline hydrochloride led to a clear increase and histamine to a significant reduction in the frequencies of the flow motion. The results of this study demonstrated that nasal flow motion could be detected and evaluated with laser-Doppler flowmetry and a special analysis of the data recorded. Specific patterns of the flow motion frequencies could be detected in the nasal mucosa that were distinctive from those of the skin. The pattern of the flow motion frequencies reacted very sensitively to the pharmacological provocations used.
“血流运动”一词代表真皮小血管平滑肌收缩状态的自发和自主节律性变化现象。关于黏膜微循环变化也有一些观察，但迄今为止尚未进行详细评估。本研究的目的是开发一种研究血流运动的方法，尤其是在鼻黏膜中；比较鼻血流运动与其他皮肤和黏膜区域的血流运动；评估生理盐水、拟交感神经药和组胺对血流运动的影响。在标准化条件下测量了40名健康志愿者鼻黏膜的微循环。在第一系列研究中，比较了前额、耳垂、鼻子和口腔黏膜的微循环。在第二系列研究中，在使用0.9%生理盐水、0.25mg盐酸羟甲唑啉作为拟交感神经制剂以及在0.5ml 0.9%生理盐水中加入0.085mg组胺激发前后，用激光多普勒血流仪测量鼻黏膜的微循环。数据评估包括使用快速傅里叶变换对微循环变化进行信号分析及其在药理刺激前后的变化。功率谱分布表明，鼻黏膜与前额和耳部皮肤的功率谱有显著差异。盐酸羟甲唑啉导致血流运动频率明显增加，组胺导致血流运动频率显著降低。本研究结果表明，血流运动可以通过激光多普勒血流仪检测和评估，并对记录的数据进行特殊分析。在鼻黏膜中可以检测到与皮肤不同的血流运动频率的特定模式。血流运动频率模式对所用的药理激发反应非常敏感。
