Otellin V A, Petrova E S
Tsitologiia. 1996;38(7):696-702.
By means of morphological methods, a study was made of effects of cyclosporin A (Cs A) on developmental dynamics in 15 day old embryo neocortex transplanted into the rat brain. It is shown that Cs A exerts no cytotoxic or cytostatic effects on grafting cells. Differentiation of grafting neuroepithelial cells into neuroblasts, young neurons and neurons in transplants of Cs A-treated rats and control transplants took place at the same time. Mitotic activity of grafting neuroepithelial cells was lower than in developing neocortex in situ; pathological mitotic forms have been described.
通过形态学方法，研究了环孢素A（CsA）对移植到大鼠脑内的15日龄胚胎新皮质发育动态的影响。结果表明，CsA对移植细胞无细胞毒性或细胞抑制作用。CsA处理组大鼠和对照组移植组织中，移植的神经上皮细胞向成神经细胞、年轻神经元和神经元的分化同时发生。移植的神经上皮细胞的有丝分裂活性低于原位发育中的新皮质；已描述了病理性有丝分裂形式。
