Kleshcheva R P
Arkh Anat Gistol Embriol. 1991 Mar;100(3):16-9.
To 31 2-3-year-old white noninbred rats transplantation of the neocortical tissue, obtained from human embryos 12-20-week-old has been performed. Under aseptic conditions after an osseous-plasty cranial trepanation (thiopental narcosis intraperitoneally) tissue pieces 2 x 3 mm have been put into an artificially made cavity in the cortex of the right parietal region. In 3-4 weeks after the operation, reparation takes place at the intracellular level both in neurons and in microglial elements, both hemispheres being involved in the process of compensatory-restoration process equivalently: realization of regeneration is performed in the brain as a single organ. The working hypertrophy of the neurons results from increase of both the perikaryon and the previously shrunken nucleus against the background of their normochromia and distinct structurally. Therefore, massive diffusive dystrophy of nervous cells disappears. Amount of microglial elements increases essentially. A close contact of neurons with satellite cells demonstrates certain activation of a single metabolic system neuron-neuroglia. Thus, xenotransplantation of the embryonal tissue of the neocortex to old animals produces a positive reparative process in involutively altered neurons and in macroglial elements.
对31只2 - 3岁的白色非近亲繁殖大鼠进行了取自12 - 20周龄人类胚胎的新皮质组织移植。在无菌条件下，经骨成形颅骨钻孔（腹腔注射硫喷妥钠麻醉）后，将2×3毫米的组织块放入右侧顶叶皮质的人工制成的腔中。术后3 - 4周，神经元和小胶质细胞成分在细胞内水平进行修复，两个半球同等程度地参与代偿性恢复过程：大脑作为一个单一器官进行再生。神经元的工作性肥大是由于核周体和先前缩小的细胞核在正常染色质和结构清晰的背景下增大所致。因此，神经细胞的大量弥漫性营养不良消失。小胶质细胞成分的数量显著增加。神经元与卫星细胞的紧密接触表明单一代谢系统神经元 - 神经胶质细胞有一定的激活。因此，将胚胎新皮质组织异种移植到老龄动物体内，会在退化性改变的神经元和大胶质细胞成分中产生积极的修复过程。
