Mont M A, Tomek I M, Hungerford D S
Department of Orthopaedic Surgery, Division of Arthritis Surgery, The Johns Hopkins University School of Medicine, Good Samaritan Hospital, Baltimore, MD, USA.
Clin Orthop Relat Res. 1997 Jan(334):124-30.
Seventy-nine knees (45 patients) with a diagnosis of avascular necrosis of the distal femur treated between 1978 and 1989 were evaluated. All patients had a corticosteroid association (had been treated with >30 mg of prednisone for >2 weeks predating by at least 6 months the onset of avascular necrosis). Thirty-two knees were managed with protected weightbearing and rest. Core decompression was performed at a minimum of 3 months after the onset of symptoms in another 47 knees. The knees treated with protected weightbearing had an average asymptomatic period of only 11 months and all but 6 (18%) proceeded to total knee replacement within 6 years. Core decompression yielded good or excellent results in 73% of the knees at an average followup of 11 years (range, 4-16 years). Of the 13 knees with failed core decompression, 7 were asymptomatic for greater than 5 years. A subset of 26 knees from each group was matched for age, gender, diagnosis, Ficat and Arlet Stage, and length of followup. The matched noncore group had 23% survival as compared with 74% survival in the core group. This long term followup suggests that core decompression may slow the rate of symptomatic progression of avascular necrosis of the knee. In addition, core decompression may extend the symptom free interval in certain patients and may delay the need for more extensive procedures such as total knee arthroplasty.
对1978年至1989年间诊断为股骨远端缺血性坏死的79个膝关节(45例患者)进行了评估。所有患者均有皮质类固醇使用史(在缺血性坏死发作前至少6个月,曾接受>30mg泼尼松治疗>2周)。32个膝关节采用保护性负重和休息治疗。另外47个膝关节在症状出现后至少3个月进行了髓芯减压。采用保护性负重治疗的膝关节平均无症状期仅为11个月,除6个膝关节(18%)外,所有膝关节均在6年内进行了全膝关节置换。髓芯减压在平均11年(范围4 - 16年)的随访中,73%的膝关节取得了良好或优异的结果。在髓芯减压失败的13个膝关节中,7个膝关节无症状超过5年。从每组中选取26个膝关节组成一个亚组,在年龄、性别、诊断、Ficat和Arlet分期以及随访时间方面进行匹配。匹配的非髓芯减压组生存率为23%,而髓芯减压组为74%。这项长期随访表明,髓芯减压可能会减缓膝关节缺血性坏死症状进展的速度。此外,髓芯减压可能会延长某些患者的无症状期,并可能推迟进行全膝关节置换等更广泛手术的必要性。