Aversa S L, Kimberlin C
Institute of Government and Public Affairs, University of Illinois, Urbana-Champaign 61801, USA.
Patient Educ Couns. 1996 Nov;29(2):207-19. doi: 10.1016/0738-3991(96)00910-x.
This study examines variables related to alteration of antiretroviral medication regimens by HIV infected persons, independent of medical advice. Perceived severity, susceptibility, benefits/barriers, cues to action, and locus of control were included in the analyses. Of 99 subjects, 37 reported discontinuing antiretrovirals on their own initiative and 36 subjects ('fiddlers') reported recent alterations in their medication regimens. Subjects who reported greater perceived barriers and pessimism and less faith in the ability of antiretrovirals to protect them from AIDS related illness were more likely to discontinue drug therapy. Fiddlers were more pessimistic and perceived more barriers to drug therapy than compliers, who believed more in the benefits of antiretrovirals. Fiddlers were significantly more internally oriented than were discontinuers. Compliers were the most optimistic about the effect of antiretrovirals. Even though compliers were more symptomatic than discontinuers, they reported their health status to be better than did discontinuers.
本研究调查了与艾滋病毒感染者自行改变抗逆转录病毒药物治疗方案相关的变量，而不考虑医疗建议。分析中纳入了感知严重性、易感性、益处/障碍、行动线索和控制点。在99名受试者中，37人报告自行停用了抗逆转录病毒药物，36名受试者（“擅自改变者”）报告其药物治疗方案近期有改变。报告感知障碍更大、更悲观且对抗逆转录病毒药物预防艾滋病相关疾病能力信心较低的受试者更有可能停止药物治疗。与认为抗逆转录病毒药物益处更多的依从者相比，擅自改变者更悲观，且感知到更多药物治疗障碍。擅自改变者比停药者更倾向于内归因。依从者对抗逆转录病毒药物的效果最为乐观。尽管依从者比停药者症状更多，但他们报告的健康状况比停药者更好。
