Sprecher D L, Morrison J A, Simbartl L A, Schreiber G B, Sabry Z I, Biro F M, Barton B A
Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Arch Pediatr Adolesc Med. 1997 Jan;151(1):84-90. doi: 10.1001/archpedi.1997.02170380088014.
To define racial differences in lipoprotein and apolipoprotein levels in girls aged 9 to 10 years.
Baseline analysis of a prospective cohort study.
Three clinical sites.
A total of 1871 black and white girls, aged 9 to 10 years, with complete maturation data (pubic hair and areolar development and menarche) and an 8-hour fast before blood draw.
Anthropometric measures and serum lipid, lipoprotein, and apolipoprotein levels.
All analyses were adjusted for maturational differences between blacks and whites (areolar or pubic hair development and menarche). The mean body mass index was marginally higher in black girls than in white girls (18.9 vs 18.3 kg/m2; P = .002), while the sum of skinfolds (34.5 vs 34.8 mm; P = .77) was equivalent. However, both body mass measures were skewed higher at the upper percentiles in black girls. The low-density lipoprotein cholesterol level was similar between black and white girls. Mean triglyceride values were higher in white girls than in black girls (0.92 vs 0.79 mmol/L [81 vs 70 mg/dL]; P < .001); however, these differences were most pronounced in the upper percentiles. Conversely, mean high-density lipoprotein cholesterol and apolipoprotein A-I levels were higher in black girls than in white girls (1.44 vs 1.37 mmol/L [56 vs 39 mg/dL] and 147 vs 138 mg/dL, respectively; both P < .001); and again the differences were most evident at the upper end of the distributions.
Racial differences in the mean levels of triglycerides, high-density lipoprotein cholesterol, and body mass in girls in the National Heart, Lung, and Blood Institute Growth and Health Study (NGHS) at age 9 to 10 years were predominantly the result of differences observed at the upper end of the distributions. The reported black-white differences for mean high-density and low-density lipoprotein cholesterol and triglyceride levels in adult women are comparable to NGHS results. Distributional characteristics of these risk factors as well as trends in lipids, lipoproteins, and apolipoproteins, will be evaluated in an ongoing longitudinal assessment that covers the full maturational period.
确定9至10岁女孩脂蛋白和载脂蛋白水平的种族差异。
一项前瞻性队列研究的基线分析。
三个临床地点。
共有1871名9至10岁的黑人和白人女孩，具备完整的成熟度数据（阴毛、乳晕发育和初潮），且在采血前禁食8小时。
人体测量指标以及血脂、脂蛋白和载脂蛋白水平。
所有分析均针对黑人和白人之间的成熟度差异（乳晕或阴毛发育以及初潮）进行了调整。黑人女孩的平均体重指数略高于白人女孩（18.9 vs 18.3 kg/m²；P = 0.002），而皮褶厚度总和相当（34.5 vs 34.8 mm；P = 0.77）。然而，黑人女孩在较高百分位数时这两项体重指标均偏高。黑人和白人女孩的低密度脂蛋白胆固醇水平相似。白人女孩的平均甘油三酯值高于黑人女孩（0.92 vs 0.79 mmol/L [81 vs 70 mg/dL]；P < 0.001）；不过，这些差异在较高百分位数时最为明显。相反，黑人女孩的平均高密度脂蛋白胆固醇和载脂蛋白A-I水平高于白人女孩（分别为1.44 vs 1.37 mmol/L [56 vs 39 mg/dL]和147 vs 138 mg/dL；P均 < 0.001）；而且这些差异在分布的高端最为明显。
美国国立心肺血液研究所生长与健康研究（NGHS）中9至10岁女孩甘油三酯、高密度脂蛋白胆固醇和体重平均水平的种族差异主要是在分布高端观察到的差异所致。报告的成年女性中黑人和白人在高密度和低密度脂蛋白胆固醇及甘油三酯平均水平上的差异与NGHS的结果相当。这些危险因素的分布特征以及脂质、脂蛋白和载脂蛋白的变化趋势将在一项涵盖整个成熟期的正在进行的纵向评估中进行评估。
