Cetinkaya B, Cetinkaya E, Küçükbay H, Durmaz R
Department of Chemistry, Faculty of Science and Literature, Inönü, University, Malatya, (Turkey).
Arzneimittelforschung. 1996 Dec;46(12):1154-8.
Seventeen cyclic ureas containing imidazolidine and benzimidazoline nuclei were synthesised by the reaction of electron-rich olefins with appropriate group 16 elements. (O, S, Se, Te). The compounds synthesised were identified by 1H, 13C-NMR, FT-IR and mass spectroscopic techniques and micro analysis. All compounds studied in this work were screened for their in vitro antimicrobial activity against standard strains: Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). Eight of the compounds were found effective to inhibit the growth of Gram-positive bacteria (Enterococcus faecalis and Staphylococcus aureus) at MIC values between 25-400 micrograms/ml. None of the compounds exhibit antimicrobial activity against gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) at the concentrations studied (6.25-800 micrograms/ml).
通过富电子烯烃与合适的第16族元素（氧、硫、硒、碲）反应，合成了17种含有咪唑烷和苯并咪唑啉核的环状脲。通过1H、13C - NMR、傅里叶变换红外光谱（FT - IR）和质谱技术以及微量分析对合成的化合物进行了鉴定。对本研究中所有化合物针对标准菌株粪肠球菌（ATCC 29212）、金黄色葡萄球菌（ATCC 29213）、大肠杆菌（ATCC 25922）和铜绿假单胞菌（ATCC 27853）进行了体外抗菌活性筛选。发现其中8种化合物在25 - 400微克/毫升的最低抑菌浓度（MIC）值下能有效抑制革兰氏阳性菌（粪肠球菌和金黄色葡萄球菌）的生长。在所研究的浓度（6.25 - 800微克/毫升）下，没有一种化合物对革兰氏阴性菌（大肠杆菌和铜绿假单胞菌）表现出抗菌活性。
