Cetinkaya B, Cetinkaya E, Küçükbay H, Durmaz R
Department of Chemistry, Faculty of Science and Literature, Inönü University, Malatya, Turkey.
Arzneimittelforschung. 1996 Aug;46(8):821-3.
Twenty-four carbene-rhodium(I), carbene-ruthenium(II) complexes and related compounds were evaluated for their in vitro antimicrobial activity against the Gram-positive bacteria Enterococcus faecalis (ATCC 29212) and Staphylococcus aureus (ATCC 29213) and Gram-negative bacteria Escherichia coli (ATCC 25922), Pseudmonas aeruginosa (ATCC 27853). The compounds 1, 2, 3, 5, 7, 8, 9, 16, 18 and 19 were found very effective to inhibit the growth of Enterococcus faecalis and Staphylococcus aureus at the minimum inhibitory concentrations (MICs) of 5, 25, 5, 50, 25, 24, 24, 24, 6.25and 12.5 micrograms/ml, respectively. The compounds 6, 10, 12, 14, 15 and 17 were significantly effective against Enterococcus faecalis and Staphylococcus aureus with MIC values of 100-200 micrograms/ml. The compounds 2, 6 and 11 were also significantly effective against Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa with MIC values of 200-400 micrograms/ml.
对24种卡宾-铑（I）、卡宾-钌（II）配合物及相关化合物进行了体外抗菌活性评估，测试其对革兰氏阳性菌粪肠球菌（ATCC 29212）、金黄色葡萄球菌（ATCC 29213）以及革兰氏阴性菌大肠杆菌（ATCC 25922）、铜绿假单胞菌（ATCC 27853）的抗菌活性。发现化合物1、2、3、5、7、8、9、16、18和19对粪肠球菌和金黄色葡萄球菌具有很强的抑制作用，其最低抑菌浓度（MIC）分别为5、25、5、50、25、24、24、24、6.25和12.5微克/毫升。化合物6、10、12、14、15和17对粪肠球菌和金黄色葡萄球菌也有显著效果，MIC值为100 - 200微克/毫升。化合物2、6和11对大肠杆菌（ATCC 25922）和铜绿假单胞菌也有显著效果，MIC值为200 - 400微克/毫升。
