Weber K, Mengs U, Schwarz T, Becker H, Lentzen H
RCC Research & Consulting Company Ltd., Itingen, Switzerland.
Arzneimittelforschung. 1996 Dec;46(12):1174-8.
Lektinol, is a special mistletoe preparation (SMP) with immunostimulatory activity, standardized with respect to bioactive mistletoe lectin, one of the most active components of mistletoe. In the present study, stimulation of leukopoiesis by SMP was investigated in mice after induction of myelosuppression by the cytostatic agent cyclophosphamide (CP). Under the experimental conditions described, CP induced severe leukopenia followed by a recovery phase where leukopoiesis was distinctly enhanced in mice treated additionally with SMP at daily intravenous doses in a range of 30 to 5000 microliters/kg body weight. This phenomenon was mainly due to a stimulation of granulopoiesis resulting in a stronger increase of metamyelocyte and mature neutrophil counts in the peripheral blood.
莱克替诺是一种具有免疫刺激活性的特殊槲寄生制剂（SMP），它以槲寄生生物活性凝集素为标准进行制备，槲寄生生物活性凝集素是槲寄生最具活性的成分之一。在本研究中，在通过细胞抑制剂环磷酰胺（CP）诱导小鼠骨髓抑制后，研究了SMP对小鼠白细胞生成的刺激作用。在所描述的实验条件下，CP诱导了严重的白细胞减少，随后进入恢复阶段，在此阶段，以每日静脉注射剂量在30至5000微升/千克体重范围内额外给予SMP治疗的小鼠，其白细胞生成明显增强。这种现象主要是由于粒细胞生成受到刺激，导致外周血中晚幼粒细胞和成熟中性粒细胞数量有更强增加。
