Versavel M, van Laack D, Evertz C, Meier F, Kuhlmann J
Bayer AG, Institute of Clinical Pharmacology, Pharma Research Center, Wuppertal, Germany.
Arzneimittelforschung. 1996 Dec;46(12):1179-85.
197 native, drug-free healthy young volunteers performed psychometric tests on a single occasion, using a new multi-user computerized test system which consists of tests of simple reaction time, complex reaction time, vigilance, concentration, motor coordination, short-term memory (word pairs or figures) and abstract language-free reasoning (2 versions). Normality of distribution of all psychometric variables was checked. For the reasoning tests and the memory tests, internal consistency and parallel test reliability were determined. Cross-correlations between the variables and factor analysis were done to evaluate whether different tests measure different brain functions. Multivariate variance analysis was carried out to test the effect of the independent factors school education, gender and age on the performance in the psychometric tests. Subjects with a lower school education level performed worse in the reasoning tests, the concentration test and the memory tests. Females were slower in the coordination test and made fewer correct solutions in the concentration test. Older subjects performed worse in the reasoning tests and had a longer working time in the memory tests than younger ones. The results show the necessity of psychometric screening of volunteers before recruitment for clinical pharmacological psychometric studies in order to reduce-individual variability.
197名未服用药物的健康本土年轻志愿者使用一种新的多用户计算机化测试系统一次性进行了心理测量测试，该系统包括简单反应时间、复杂反应时间、警觉性、注意力、运动协调性、短期记忆（单词对或数字）和抽象无语言推理（2个版本）测试。检查了所有心理测量变量的分布正态性。对于推理测试和记忆测试，确定了内部一致性和平行测试信度。对变量进行交叉相关分析和因子分析，以评估不同测试是否测量不同的脑功能。进行多变量方差分析，以测试学校教育、性别和年龄等独立因素对心理测量测试表现的影响。学校教育水平较低的受试者在推理测试、注意力测试和记忆测试中的表现较差。女性在协调性测试中速度较慢，在注意力测试中正确解答较少。年龄较大的受试者在推理测试中的表现较差，在记忆测试中的工作时间比年轻受试者长。结果表明，在招募志愿者进行临床药理心理测量研究之前，有必要对志愿者进行心理测量筛选，以减少个体差异。
