含膜噬菌体PRD1的组装依赖于GroEL和GroES。
Assembly of membrane-containing bacteriophage PRD1 is dependent on GroEL and GroES.
作者信息
Hänninen A L, Bamford D H, Bamford J K
机构信息
Division of Genetics, University of Helsinki, 00014, Finland.
出版信息
Virology. 1997 Jan 6;227(1):207-10. doi: 10.1006/viro.1996.8308.
PMID:9007074
Abstract
Assembly of the broad-host-range bacteriophage PRD1 involves translocation of the virus-specific membrane to the inside of the icosahedral protein shell formed of trimeric coat proteins. The formation of PRD1 particles is, in addition to the virus-encoded assembly factors P10 and P17, dependent on GroEL/GroES chaperonins. The chaperonins assist in the folding of the capsid proteins P3 and P5 and in the assembly of viral membrane proteins.
摘要
广宿主范围噬菌体PRD1的组装涉及病毒特异性膜向由三聚体衣壳蛋白形成的二十面体蛋白质外壳内部的转运。除了病毒编码的组装因子P10和P17外，PRD1颗粒的形成还依赖于GroEL/GroES伴侣蛋白。这些伴侣蛋白有助于衣壳蛋白P3和P5的折叠以及病毒膜蛋白的组装。
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