Gäfvert E, Bordalo O, Karlberg A T
Department of Occupational Health, National Institute for Working Life, Solna, Sweden.
Contact Dermatitis. 1996 Nov;35(5):290-8. doi: 10.1111/j.1600-0536.1996.tb02391.x.
Most rosin (colophony) used today is chemically modified. Will contact allergy to modified rosin be overlooked when testing is performed with only unmodified rosin in the standard series? 2 components from modified rosins, maleopimaric acid (MPA) and glyceryl I-monoabietate (GMA), earlier identified as contact allergens, were added to the patch test standard series. Some commonly-used modified rosin products were also tested. Positive reactions were observed to the modified components MPA and GMA. Of the patients with positive reactions to MPA and GMA, several did not react to unmodified rosin in the standard series. No reaction was observed to the modified rosin products without a concomitant reaction to unmodified rosin. The positive reactions observed to the modified rosins may be due to residual unmodified material in the product, but a possible contribution from allergenic modified rosin components cannot be disregarded. When a patient's history indicates a rosin allergy, but a negative response to unmodified rosin in the standard series is observed, additional testing with GMA and MPA or, second best, with glycerol-esterified rosin and maleic-anhydride-modified rosin is recommended. Some modified rosin products, which could be used for additional testing, are suggested.
如今使用的大多数松香（松脂）都经过了化学改性。当仅用标准系列中的未改性松香进行测试时，对改性松香的接触性过敏会被忽视吗？改性松香中的两种成分，马来海松酸（MPA）和甘油单枞酸酯（GMA），此前已被确定为接触性过敏原，被添加到斑贴试验标准系列中。一些常用的改性松香产品也进行了测试。观察到对改性成分MPA和GMA有阳性反应。在对MPA和GMA呈阳性反应的患者中，有几人对标准系列中的未改性松香没有反应。对未伴随未改性松香反应的改性松香产品未观察到反应。观察到的对改性松香的阳性反应可能是由于产品中残留的未改性物质，但不能忽视致敏性改性松香成分的可能作用。当患者的病史表明有松香过敏，但在标准系列中对未改性松香的反应为阴性时，建议用GMA和MPA进行额外测试，或者次选，用甘油酯化松香和马来酸酐改性松香进行测试。文中还给出了一些可用于额外测试的改性松香产品。
