Taga M, Saji M, Suyama K, Minaguchi H
Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Japan.
J Endocrinol Invest. 1996 Nov;19(10):659-62. doi: 10.1007/BF03349035.
In order to clarify the biological action of transforming growth factor alpha (TGF-alpha) in the human decidua, we investigated the effects of TGF-alpha on cell proliferation and prolactin (PRL) secretion in cultured decidual cells in vitro. TGF-alpha had a stimulatory effect on DNA synthesis in decidual cells and an inhibitory effect on PRL secretion from these cells. These results suggest that TGF-alpha, like epidermal growth factor (EGF), may be one of the substances which regulate decidual function.
为阐明转化生长因子α（TGF-α）在人蜕膜中的生物学作用，我们在体外研究了TGF-α对培养的蜕膜细胞中细胞增殖及催乳素（PRL）分泌的影响。TGF-α对蜕膜细胞的DNA合成有刺激作用，对这些细胞的PRL分泌有抑制作用。这些结果表明，TGF-α与表皮生长因子（EGF）一样，可能是调节蜕膜功能的物质之一。
