Smith T P, Lee V S, Hudson E R, Newman G E, Payne C S, Suhocki P V, McDermott V G, Stackhouse D J
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
J Vasc Interv Radiol. 1996 Mar-Apr;7(2):207-12. doi: 10.1016/s1051-0443(96)70763-7.
To determine the effects of pulmonary angiography performed with low-osmolar, nonionic contrast media on pulmonary artery pressures.
In a prospective, uncontrolled clinical trial, pulmonary artery pressures (systolic, diastolic, mean) of 116 patients referred for pulmonary angiography were recorded before and 1 and 5 minutes after injection of contrast material.
There was a statistically significant rise in systolic, diastolic, and mean pulmonary artery pressure at 1 minute (4.6, 3.4, 4.1 mm Hg, respectively) and 5 minutes (3.8, 2.7, 3.4 mm Hg, respectively) after the initial contrast material injection (P < .05). Increases were smaller with additional injections. Systolic pressure changes at 1 and 5 minutes after the first injection were linearly dependent on the volume of contrast material injected (P < .05). There was no statistically significant difference in the increase in pulmonary artery pressure between patients with pulmonary embolus or pulmonary arterial hypertension and those without.
There is a small but statistically significant rise in pulmonary artery pressure after injection of low-osmolar, nonionic contrast material for pulmonary angiography; it is unlikely to be of clinical significance.
确定使用低渗非离子型造影剂进行肺血管造影对肺动脉压的影响。
在一项前瞻性非对照临床试验中，记录了116例因肺血管造影而就诊患者在注射造影剂前、注射后1分钟和5分钟时的肺动脉压（收缩压、舒张压、平均压）。
首次注射造影剂后1分钟（分别为4.6、3.4、4.1毫米汞柱）和5分钟（分别为3.8、2.7、3.4毫米汞柱）时，收缩压、舒张压和平均肺动脉压均有统计学意义的升高（P <.05）。额外注射时升高幅度较小。首次注射后1分钟和5分钟时的收缩压变化与注射的造影剂体积呈线性相关（P <.05）。有肺栓塞或肺动脉高压患者与无此类疾病患者之间，肺动脉压升高无统计学显著差异。
注射低渗非离子型造影剂进行肺血管造影后，肺动脉压有小幅度但具有统计学意义的升高；这不太可能具有临床意义。
