Smit E M, van Beek E J, Bakker A J, Reekers J A
University of Amsterdam, Department of Radiology, The Netherlands.
Acad Radiol. 1995 Jul;2(7):609-13. doi: 10.1016/s1076-6332(05)80126-6.
We compared the hemodynamic responses to ionic and nonionic low-osmolar contrast media of patients who underwent pulmonary angiography.
Ninety-nine consecutive patients with suspected pulmonary emboli were randomly assigned to receive either 40 ml iohexol or 40 ml ioxaglate in 2 sec at 600 psi (0.17 kg/m2). Mean pulmonary arterial pressure, pulse rate, and blood pressure were recorded before, immediately after, and 2, 5, and 10 min following injection. Image quality was assessed by readers who were unaware of drug assignment.
Pulmonary arterial pressure increased to a maximum at 2 min and was higher in patients with pulmonary emboli (p = .06). There were no significant differences between the two contrast media used. The systolic blood pressure and pulse rate in patients with pulmonary emboli increased significantly more in the ioxaglate group (ps = .03 and .04, respectively). Image quality was excellent in 90% of both groups.
Both contrast agents are safe for pulmonary angiography and yield similar image quality. There appears to be a positive inotropic effect of ioxaglate.
我们比较了接受肺血管造影术患者对离子型和非离子型低渗造影剂的血流动力学反应。
99例连续的疑似肺栓塞患者被随机分配，在600磅力/平方英寸（0.17千克/平方米）压力下于2秒内接受40毫升碘海醇或40毫升碘克沙醇。在注射前、注射后即刻以及注射后2、5和10分钟记录平均肺动脉压、脉搏率和血压。由不知道药物分配情况的阅片者评估图像质量。
肺动脉压在2分钟时升至最高，肺栓塞患者的肺动脉压更高（p = 0.06）。所使用的两种造影剂之间无显著差异。碘克沙醇组肺栓塞患者的收缩压和脉搏率升高更为显著（分别为p = 0.03和0.04）。两组90%的图像质量均为优秀。
两种造影剂用于肺血管造影均安全且产生相似的图像质量。碘克沙醇似乎有正性肌力作用。
