[Kinetics of reappearance of suppressed allotypes in multiheterozygous rabbits (author's transl)].

Heterozygous rabbits of genotype a1n81f73g74/a2n82f71g75 were injected at birth with anti-al antiserum. The suppression of the VHa1 allotype resulted in a similar concommitant suppression of the constant region allotypes coded by genes of the same allogroup as a1. After 3 to 4 months the suppressed allotypes were re-expressed in measurable amounts. At 6 months in the 3 suppressed animals, the proportion of suppressed allotypes (S) to the non-suppressed ones (NS) was higher among colostrum and serum IgA (50% S, 50% NS) than among IgG for IgM. Among these two latter classes the proportion S/(S + NS) remained low (about 15% S, 85% NS) over an 18 month period in two out of three suppressed rabbits. In the third one, the proportion S/(S + NS) among IgG molecules increased to increasing concentration of S allotypes is not compensated by a decrease in concentrations of NS allotypes. The study of these phenomena could bring a better understanding of mechanisms involved in regulation of Ig synthesis and in allotype suppression.