Ratcliffe M J, Ivanyi J
Eur J Immunol. 1981 Apr;11(4):301-6. doi: 10.1002/eji.1830110407.
Injection of M-1 (Cmu), G-1 (Cgamma) heterozygous chickens on the day of hatch with anti-IgM-1 antiserum induced allotype suppression from which chickens recovered over a period of approximately 4 months. The suppression of the serum IgM-1 levels was matched by a decrease in the number of splenic and peripheral blood B cells bearing the relevant IgM-1 allotype, and a compensatory increase in the number of cells bearing the alternative nonsuppressed IgM-1 allotype. However, the proportion of IgM-1 bearing bursal cells was only marginally altered. The recovery from suppression was due to B cell recruitment and could be abrogated by bursectomy. Allotype suppression induced in ovo or maintained by repeated injection of anti-IgM-1 anti-serum resulted in chronic suppression and depletion of the relevant peripheral as well as bursal IgM-1-bearing cells. Antibody titers of the relevant allotype in partially suppressed chickens generally correlated with serum allotype levels without clonal restriction in antibody response of the suppressed allotype.
在孵化当天给M-1（Cmu）、G-1（Cgamma）杂合子鸡注射抗IgM-1抗血清可诱导同种异型抑制，鸡在大约4个月的时间内恢复。血清IgM-1水平的抑制与携带相关IgM-1同种异型的脾和外周血B细胞数量的减少相匹配，以及携带替代的未被抑制的IgM-1同种异型的细胞数量的代偿性增加。然而，携带IgM-1的法氏囊细胞比例仅略有改变。从抑制中恢复是由于B细胞募集，并且可通过法氏囊切除消除。在卵内诱导或通过反复注射抗IgM-1抗血清维持的同种异型抑制导致相关外周以及法氏囊中携带IgM-1的细胞的慢性抑制和耗竭。部分受抑制鸡中相关同种异型的抗体滴度通常与血清同种异型水平相关，而在受抑制同种异型的抗体反应中无克隆限制。
