Hartmann A, Blaszyk H, Kovach J S, Sommer S S
University of Regensberg, Germany.
Trends Genet. 1997 Jan;13(1):27-33. doi: 10.1016/s0168-9525(96)10043-3.
The P53 tumor-suppressor gene is an advantageous tool for analyzing the molecular epidemiology of cancer. We describe the utility of the P53 gene as a 'mutagen test' and a prognostic indicator in breast cancer. Aspects of study design and methodology are discussed. Two major conclusions emerge: (1) there is an extraordinary diversity of mutational patterns among cohorts, hinting that the unique biology of mammary cells results in exposure to high doses of a diversity of ingested lipophilic mutagens; and (2) mutations in the P53 gene predict poor outcome in breast cancer.
P53肿瘤抑制基因是分析癌症分子流行病学的一个有利工具。我们描述了P53基因作为乳腺癌“诱变测试”和预后指标的效用。讨论了研究设计和方法的各个方面。得出了两个主要结论：（1）不同队列之间的突变模式存在异常多样性，这表明乳腺细胞的独特生物学特性导致其接触高剂量的多种摄入性亲脂性诱变剂；（2）P53基因的突变预示着乳腺癌的不良预后。
