Ponec M, Frölich M, de Lijster A, Moolenaar A J
Arch Dermatol Res (1975). 1977 Jul 21;259(1):63-70. doi: 10.1007/BF00562738.
In this paper a method for the radioimmunological determination of triamcinolone acetonide (TAAc) in plasma is described. The antiserum used in the radioimmunological determinations showed high specifity for TAAc; the minimal detectable amount was 0.2 ng. The course of the plasma concentration-time curve of TAAc after intravenous injection into rats was analysed. The concentration of TAAc in the blood of the patients after topical application of the drug is very low. No detectable amount of TAAc was found in the blood of out-patients. Hospitalized patients treated with TAAc under plastic occlusion showed plasma levels ranging from 0.8 to 3.4 ng/ml. This level remained constant throughout the treatment.
本文描述了一种放射免疫法测定血浆中曲安奈德（TAAc）的方法。放射免疫测定中使用的抗血清对TAAc具有高特异性；最小可检测量为0.2 ng。分析了大鼠静脉注射TAAc后血浆浓度-时间曲线的过程。局部应用该药物后患者血液中TAAc的浓度非常低。门诊患者血液中未检测到TAAc。在塑料封闭条件下接受TAAc治疗的住院患者血浆水平为0.8至3.4 ng/ml。在整个治疗过程中该水平保持恒定。
