Coll-Fresno P M, Batoz M, Tarquin S, Birnbaum D, Coulier F
Laboratoire d'Oncologie Moléculaire, Unité 119 de I'Institut Nationalde la Santé Et de la Recherche Médicale, Marseille, France.
Oncogene. 1997 Jan 16;14(2):243-7. doi: 10.1038/sj.onc.1200826.
The FGFs constitute a family of, at least, 12 polypeptides (FGF1 to FGF12) implicated in a number of physiological and pathological processes throughout embryogenesis and adult life. They bind to at least three types of cell surface molecules, including four high affinity transmembrane tyrosine kinase receptors (FGFR1 to FGFR4). In addition to important roles during development, FGF involvement in pathological conditions, including tumour formation, has been suspected, and overexpression of FGFR in tumour specimens is well documented. Diphtheria Toxin/FGF6 (DT/FGF6) mitotoxin has been shown to selectively and effectively target FGFR1-expressing cells. We show here that DT/FGF6 targets myoblasts engineered to express either one of the four FGFR, as well as FGFR-expressing tumour cells.
