Karlsberg R P, Lacher J W, Bartecchi C E
Arch Intern Med. 1977 Sep;137(9):1155-7.
We describe here a family with hemolytic-uremic syndrome culminating in renal failure and severe hypertension in the involved male adults. Members of this family developed a microangiopathic hemolytic anemia, progressive renal failure, the onset of elevation of blood pressure, and an untimely death in young adulthood. One affected family member has survived the initial crisis. The family history presents further evidence for an autosomal dominant pattern of inheritance of hemolytic-uremic syndrome with presentation in adulthood.
我们在此描述一个患有溶血性尿毒症综合征的家族，该家族中患病的成年男性最终发展为肾衰竭和严重高血压。这个家族的成员出现了微血管病性溶血性贫血、进行性肾衰竭、血压升高以及在年轻时过早死亡的情况。有一位受影响的家族成员在最初的危机中幸存下来。家族病史为溶血性尿毒症综合征成年期发病的常染色体显性遗传模式提供了进一步证据。
