[Xenotransplantation].

A Bulk of studies on xenotransplantation have been accumulated for the last few years. Most of the studies focus in the investigation for etiologic mechanism of hyperacute rejection seen in the xenotransplantation between distant species. Underlying pathophysiology in hyperacute rejection is primarily based on initial antigen-antibody reaction between oligosaccharide epitope of the xenogeneic organ and natural antibody in the recipient plasma. Subsequent activation of complement cascade and activation of the endothelial cell constitute an integral part of the entire complexity of the hyperacute rejection. We herein summarize the updated knowledge and provide an overview on this interesting research field.