DeWitt R T, Feinstein D I
Arch Intern Med. 1977 Sep;137(9):1211-3.
A hemophilliac with a factor VIII inhibitor was bleeding massively from an extensive surgical wound. After ten days of unsuccessful management by conservative measures, he was given a single infusion of prothrombin complex concentrate (Konyne). Bleeding stopped immediately and the wound healed without further recurrence of bleeding. Although the activated partial thromboplastin time shortened following the infusion, the exact physiologic mechanism whereby these concentrates bypass the need for factor VIII clotting activity is unknown.
一名患有因子 VIII 抑制剂的血友病患者因大面积手术伤口大量出血。在采取保守措施治疗十天无果后，给他单次输注了凝血酶原复合物浓缩剂（科宁）。出血立即停止，伤口愈合且未再次出血。尽管输注后活化部分凝血活酶时间缩短，但这些浓缩剂绕过对因子 VIII 凝血活性需求的确切生理机制尚不清楚。
