Rasche H, Bindewald H, Köhle W, Scheck R, Heinrich R, Seibert K
Dtsch Med Wochenschr. 1977 Mar 4;102(9):319-23. doi: 10.1055/s-0028-1104885.
Severe rectal bleeding in a 6-year-old boy with haemophilia A and factor VIII inhibitors could not be stopped with factor VIII concentrates. But a good effect was achieved with activated prothrombin complex concentrates (fraction FEIBA), given over eight days. Amaurosis occurred as a complication after injection of the first dose, but disappeared completely within several minutes. Tests revealed accelerated intravascular coagulation with increased fibrin monomers and fibrin/fibrinogen degradation products.
