Danese C, Borgia M C, Ferranti E, Zavattaro E, Epiceno A N, Marcianó F
Università degli Studi di Roma, La Sapienza, Il Istituto Clinica Medica.
Minerva Cardioangiol. 1996 Nov;44(11):529-33.
The aim of this study was to evaluate plasma levels of lipoprotein (a) [LP(a)] and plasminogen in patients affected with atherosclerotic disease and to understand the mutual relationships. Eighty-four patients affected with atherosclerosis were examined and divided as follows: group I, 24 patients with peripheral arteriopathy; group II, 40 patients with ischemic heart disease (myocardial infarction and/or angina pectoris); group III, 20 patients with multi-infarct dementia; group IV (control group) with 20 healthy young subjects. The results show that Lp(a) plasma levels, in atherosclerotic patients, are higher than 30 mg/dl, while the plasminogen levels are lower than 80 mg/dl. There is an inverse correlation between these two data. Moreover, a different behaviour of Lp(a) and plasminogen rate related to age of patients, to number of atherosclerotic lesions or to acuteness of ischemic heart disease, was observed.
本研究旨在评估动脉粥样硬化疾病患者的血浆脂蛋白(a)[LP(a)]和纤溶酶原水平，并了解它们之间的相互关系。对84例动脉粥样硬化患者进行了检查，并分为以下几组：第一组，24例患有外周动脉病；第二组，40例患有缺血性心脏病（心肌梗死和/或心绞痛）；第三组，20例患有多发梗死性痴呆；第四组（对照组）为20名健康年轻受试者。结果显示，动脉粥样硬化患者的LP(a)血浆水平高于30mg/dl，而纤溶酶原水平低于80mg/dl。这两个数据之间呈负相关。此外，还观察到LP(a)和纤溶酶原比率与患者年龄、动脉粥样硬化病变数量或缺血性心脏病的严重程度之间存在不同的关系。
