Nomura S
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Hiroshima J Med Sci. 1995 Dec;44(4):133-9.
Serum lipoprotein(a) [Lp(a)] was determined in 85 healthy controls (control group), in 49 patients with cerebrovascular disease (CVD group), and in 87 patients with acute myocardial infarction (AMI group). Lp(a) concentration was measured using a single radial immunodiffusion method. Because Lp(a) showed a skewed distribution, Lp(a) was plotted in each group on a box plot and analyzed using non-parametric methods. The following results were obtained: 1) Lp(a) levels were significantly higher in both the AMI and CVD groups than in the control group. 2) The CVD group was divided into 4 groups: [1] cerebral hemorrhage (HEM); [2] cardioembolic infarction (EMB); [3] lacunar infarction (LAC); and [4] atherothrombotic infarction (THR). In the THR group, Lp(a) concentration was higher than those in the control and LAC groups. 3) In the CVD group, patients with an elevated Lp(a) value showed severe lesions in the major cerebral arteries evaluated by cerebral arteriograms. 4) In the AMI patients who underwent coronary angiography, the Lp(a) level showed a marked increase with an increase in the number of affected vessels. The correlation between coronary index (CI) and Lp(a) was also investigated. The lesion severity of coronary arteries was correlated with serum Lp(a) concentration. These results suggest that a high Lp(a) value is linked to atherosclerosis of the cerebral and coronary arteries, and influences its severity.
对85名健康对照者（对照组）、49名脑血管疾病患者（CVD组）和87名急性心肌梗死患者（AMI组）测定了血清脂蛋白(a)[Lp(a)]。采用单向免疫扩散法测量Lp(a)浓度。由于Lp(a)呈偏态分布，因此在每组中绘制Lp(a)的箱线图，并使用非参数方法进行分析。获得了以下结果：1）AMI组和CVD组的Lp(a)水平均显著高于对照组。2）CVD组分为4组：[1]脑出血（HEM）；[2]心源性栓塞性梗死（EMB）；[3]腔隙性梗死（LAC）；[4]动脉粥样硬化血栓形成性梗死（THR）。在THR组中，Lp(a)浓度高于对照组和LAC组。3）在CVD组中，Lp(a)值升高的患者在经脑血管造影评估的主要脑动脉中显示出严重病变。4）在接受冠状动脉造影的AMI患者中，Lp(a)水平随着受累血管数量的增加而显著升高。还研究了冠状动脉指数（CI）与Lp(a)之间的相关性。冠状动脉病变严重程度与血清Lp(a)浓度相关。这些结果表明，高Lp(a)值与脑动脉和冠状动脉粥样硬化有关，并影响其严重程度。
