Hinze-Selch D, Mullington J, Pollmächer T
Max-Planck-Institut für Psychiatrie, Klinisches Institut, München, Deutschland.
Wien Med Wochenschr. 1996;146(13-14):311-3.
In 27 schizophrenic patients we investigated plasma levels of cytokines before the initiation of treatment and after the first, second and sixth week of treatment with the atypical antipsychotic agent clozapine. In addition, we did polysomnographic recordings in one schizophrenic patient prior to, during and following clozapine-induced fever. We found that independently of fever clozapine significantly increased the plasma levels of tumor-necrosis-factor a (TNFa) and soluble interleukin-2-receptor (sIL-2r) which were further increased by fever. Interleukin-6 (IL-6) was increased only together with fever and showed a significant positive correlation with clozapine-induced fever. The sleep recording of the fever night revealed severely disturbed sleep. Possible links between the clozapine-induced release of cytokines and clozapine's effect on night sleep are discussed.
我们对27例精神分裂症患者在开始使用非典型抗精神病药物氯氮平治疗前以及治疗的第一周、第二周和第六周后检测了血浆细胞因子水平。此外，我们对1例精神分裂症患者在氯氮平引起发热之前、期间和之后进行了多导睡眠图记录。我们发现，与发热无关，氯氮平显著提高了肿瘤坏死因子α（TNFα）和可溶性白细胞介素-2受体（sIL-2r）的血浆水平，而发热进一步提高了这些水平。白细胞介素-6（IL-6）仅在发热时升高，并且与氯氮平引起的发热呈显著正相关。发热当晚的睡眠记录显示睡眠严重紊乱。本文讨论了氯氮平诱导的细胞因子释放与氯氮平对夜间睡眠影响之间的可能联系。
