Lü Lu-xian, Guo Su-qin, Chen Wei, Li Qiang, Cheng Jun, Guo Jing-hua
Second Affiliated Hospital, Xinxiang Medical College, Xinxiang 453002, China.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Nov;24(11):1251-4.
To study the effects of clozapine and risperidone on serum cytokine levels in patients with first-episode paranoid schizophrenia, and explore the role of the cytokines in the psychopathological basis of the illness.
Fifty-eight patients with first-episode paranoid schizophrenia were treated with either clozapine or risperidone, and before and at the end of the 4th, 8th weeks and 6th months after the medication respectively, the serum levels of interleukin (IL)-6, 2, 18,and tumor necrosis factor (TNF)alpha were measured with enzyme-linked immunosorbent assay (ELISA). The Positive and Negative Syndrome Scale (PANSS) was used to evaluate the psychotic symptoms.
In patients treated with risperidone, the levels of serum IL-6 and IL-2 after 4 weeks, TNFalpha after 8 weeks, and IL-18 after 6 months were all significantly lowered in comparison with the pretreatment levels (P<0.01 or 0.05). In clozapine group, the levels of IL-2 after 4 weeks and IL-6 and IL-18 after 6 months were lowered significantly (P<0.01 or 0.05). Before the medication, serum IL-6 level was positively correlated with Positive Syndrome scores (r=0.386, P<0.01), IL-2 with the total score and Positive Syndrome scores (r=0.338, 0.305; P<0.01, 0.05), and TNFalpha with the total score (r=0.283, P<0.05). The changes of IL-2 and IL-6 after 8 weeks was positively correlated with the change of Positive Syndrome scores (r=0.268, 0.375; P<0.05, 0.01). Six months after the medication, the change in IL-6 and TNFalpha levels was positively correlated with the change of total score (r=0.365, 0.362; P<0.05). Before treatment, IL-6 was positively correlated with IL-2 levels (r=0.356, P<0.01), and TNFalpha with IL-18 levels (r=0.291, P<0.05). TNFalpha was positively correlated with IL-6 levels (r=0.332, P<0.01) 8 weeks after the medication. The changes in IL-6 was positively correlated with the those in IL-2 levels 6 months after the medication (r=0.391, P< 0.05).
Clozapine and risperidone have similar immunosuppression actions and may affect serum IL-6 levels in patients with paranoid schizophrenia, in the psychopathology of which the cytokines play their roles of various importance.
研究氯氮平和利培酮对首发偏执型精神分裂症患者血清细胞因子水平的影响，并探讨细胞因子在该疾病精神病理学基础中的作用。
58例首发偏执型精神分裂症患者分别接受氯氮平或利培酮治疗，在用药前及用药后第4、8周和6个月时，采用酶联免疫吸附测定（ELISA）法检测血清白细胞介素（IL）-6、2、18及肿瘤坏死因子（TNF）α水平。采用阳性与阴性症状量表（PANSS）评估精神症状。
利培酮治疗组患者用药4周后血清IL-6和IL-2水平、8周后TNFα水平及6个月后IL-18水平与治疗前相比均显著降低（P<0.01或0.05）。氯氮平组患者用药4周后IL-2水平及6个月后IL-6和IL-18水平显著降低（P<0.01或0.05）。用药前，血清IL-6水平与阳性症状评分呈正相关（r=0.386，P<0.01），IL-2与总分及阳性症状评分呈正相关（r=0.338，0.305；P<0.01，0.05），TNFα与总分呈正相关（r=0.283，P<0.05）。用药8周后IL-2和IL-6的变化与阳性症状评分的变化呈正相关（r=0.268，0.375；P<0.05，0.01）。用药6个月后，IL-6和TNFα水平的变化与总分的变化呈正相关（r=0.365，0.362；P<0.05）。治疗前，IL-6与IL-2水平呈正相关（r=0.356，P<0.01），TNFα与IL-18水平呈正相关（r=0.291，P<0.05）。用药8周后TNFα与IL-6水平呈正相关（r=0.332，P<0.01）。用药6个月后IL-6的变化与IL-2水平的变化呈正相关（r=0.391，P<0.05）。
氯氮平和利培酮具有相似的免疫抑制作用，可能影响偏执型精神分裂症患者的血清IL-6水平，细胞因子在该疾病的精神病理学中发挥着不同程度的作用。
