通过二次判别分析鉴定人类基因组中的蛋白质编码区域。
Identification of protein coding regions in the human genome by quadratic discriminant analysis.
作者信息
Zhang M Q
机构信息
Cold Spring Harbor Laboratory, NY 11724, USA.
出版信息
Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):565-8. doi: 10.1073/pnas.94.2.565.
Abstract
A new method for predicting internal coding exons in genomic DNA sequences has been developed. This method is based on a prediction algorithm that uses the quadratic discriminant function for multivariate statistical pattern recognition. Substantial improvements have been made (with only 9 discriminant variables) when compared with existing methods: HEXON [Solovyev, V. V., Salamov, A. A. & Lawrence, C. B. (1994) Nucleic Acids Res. 22, 5156-5163] (based on linear discriminant analysis) and GRAIL2 [Uberbacher, E. C. & Mural, R. J. (1991) Proc. Natl. Acad. Sci. USA 88, 11261-11265] (based on neural networks). A computer program called MZEF is freely available to the genome community and allows users to adjust prior probability and to output alternative overlapping exons.
摘要
一种预测基因组DNA序列中内部编码外显子的新方法已经开发出来。该方法基于一种预测算法，该算法使用二次判别函数进行多元统计模式识别。与现有方法相比（仅使用9个判别变量）有了实质性改进：HEXON [索洛维耶夫，V. V.，萨拉莫夫，A. A. & 劳伦斯，C. B.（1994年）《核酸研究》22卷，5156 - 5163页]（基于线性判别分析）和GRAIL2 [尤伯巴赫，E. C. & 穆拉尔，R. J.（1991年）《美国国家科学院院刊》88卷，11261 - 11265页]（基于神经网络）。一个名为MZEF的计算机程序可供基因组学界免费使用，用户可以调整先验概率并输出替代的重叠外显子。
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