吸入一氧化氮对先天性心脏病患者术后肺循环的影响。

Effects of inhaled nitric oxide on postoperative pulmonary circulation in patients with congenital heart disease.

作者信息

Matsui J, Yahagi N, Kumon K, Hayashi H, Watanabe Y, Haruna M, Tanigami H, Yagihara T, Takamoto S, Kamiya T

机构信息

Department of Cardiovascular Surgery, National Cardiovascular Center, Osaka, Japan.

出版信息

Artif Organs. 1997 Jan;21(1):17-20. doi: 10.1111/j.1525-1594.1997.tb00692.x.

DOI:10.1111/j.1525-1594.1997.tb00692.x

PMID:9012900

Abstract

We studied 22 patients with residual pulmonary hypertension or symptoms of postoperative pulmonary hypertensive crisis. They received low-dose inhalation (10 ppm) of nitric oxide (NO), a selective pulmonary vasodilator, after total correction for congenital heart anomalies. Fifteen minutes of NO inhalation improved the pulmonary circulation and lessened the imbalance in the ventilation-perfusion ratio in both groups. Thus, NO inhalation is effective in the treatment of pulmonary hypertension and in the prevention of pulmonary hypertensive crises after total correction for congenital heart anomalies. All patients continued to receive NO therapeutically. The duration of such therapeutic NO inhalation was well correlated with postoperative Qp/Qs (p = 0.014) and Rp/Rs (p = 0.029).

摘要

我们研究了22例残留肺动脉高压或术后肺动脉高压危象症状的患者。他们在先天性心脏畸形完全矫正后接受了低剂量（10 ppm）一氧化氮（NO）吸入治疗，NO是一种选择性肺血管扩张剂。两组患者吸入NO 15分钟后，肺循环得到改善，通气/灌注比失衡减轻。因此，吸入NO对先天性心脏畸形完全矫正后的肺动脉高压治疗及预防肺动脉高压危象有效。所有患者均继续接受NO治疗。这种治疗性NO吸入的持续时间与术后Qp/Qs（p = 0.014）和Rp/Rs（p = 0.029）密切相关。