Atkinson K, Fay K, Nivison-Smith I, Downs K
Department of Haematology, St Vincent's Hospital, Sydney, NSW, Australia.
Bone Marrow Transplant. 1997 Jan;19(1):15-21. doi: 10.1038/sj.bmt.1700608.
In an attempt to accelerate marrow recovery after HLA-identical sibling bone marrow transplantation, the donors of 12 patients with haematological malignancy were given recombinant human granulocyte colony-stimulating factor (rHuG-CSF; lenograstim; Granocyte) 5 micrograms/kg/day for seven doses prior to marrow harvest. All 12 recipients also received lenograstim 5 micrograms/kg/day from the day of transplant until their neutrophil count was 1.0 x 10(9)/1. In addition to lenograstim post-transplant and lenograstim-stimulated donor bone marrow the first six recipients also received donor peripheral blood stem cells that had been enriched for CD34+ stem/progenitor cells and T cell depleted on an immune absorption column (cohort 1). The second six patients (cohort 2) received lenograstim post-transplant and lenograstim-stimulated donor marrow only. All 12 patients showed a marked elevation of their circulating white blood cell count (predominantly neutrophils) on day 1 post-transplant. Compared to carefully matched historical control patients the rate of neutrophil engraftment was significantly accelerated in both patient cohorts and platelet engraftment was accelerated in cohort 2.
为了加速人类白细胞抗原（HLA）匹配的同胞骨髓移植后的骨髓恢复，对12例血液系统恶性肿瘤患者的供者，在采集骨髓前给予重组人粒细胞集落刺激因子（rHuG-CSF；来格司亭；Granocyte）5微克/千克/天，共七剂。所有12例受者从移植当天起也接受来格司亭5微克/千克/天，直至其中性粒细胞计数达到1.0×10⁹/升。除了移植后使用来格司亭和用其刺激供者骨髓外，前6例受者（第1组）还接受了经免疫吸附柱富集CD34⁺干/祖细胞并去除T细胞的供者外周血干细胞。后6例患者（第2组）仅在移植后接受来格司亭和用其刺激的供者骨髓。所有12例患者在移植后第1天循环白细胞计数（主要是中性粒细胞）均显著升高。与精心匹配的历史对照患者相比，两组患者的中性粒细胞植入率均显著加快，第2组患者的血小板植入也加快。
