未受过训练的男性和女性运动时儿茶酚胺、肾素-血管紧张素系统及心房利钠肽的反应。

Responses of catecholamines, renin-angiotensin system, and atrial natriuretic peptide to exercise in untrained men and women.

Kinugawa T, Ogino K, Miyakoda H, Saitoh M, Hisatome I, Fujimoto Y, Yoshida A, Shigemasa C, Sato R

First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.

Gen Pharmacol. 1997 Feb;28(2):225-8. doi: 10.1016/s0306-3623(96)00191-7.

Abstract

Plasma norepinephrine (NE), epinephrine (E), renin activity (PRA), angiotensin II (ATII), aldosterone (ALD), and atrial natriuretic peptide (ANP) were measured in 20 male and 15 female subjects during submaximal treadmill test. 2. Exercise duration was not different between the two groups (male vs. female: 13.4 +/- 0.8 min vs. 11.6 +/- 0.7 min, ns). Female subjects had higher heart rate during exercise, while systolic blood pressure at peak exercise was higher in male subjects. 3. Plasma NE, E, ANP, and ATII responses were comparable between male and female subjects, but PRA both at rest and during exercise and ALD at rest were significantly higher in male subjects. 4. Cardiac responses to submaximal exercise were different between male and female subjects, but neurohormonal responses were comparable between the two groups except for the high PRA at rest and during exercise and high plasma ALD at rest in male subjects.

摘要

在20名男性和15名女性受试者进行次极量平板运动试验期间，测量了血浆去甲肾上腺素（NE）、肾上腺素（E）、肾素活性（PRA）、血管紧张素II（ATII）、醛固酮（ALD）和心房利钠肽（ANP）。2. 两组之间的运动持续时间无差异（男性与女性：13.4±0.8分钟对11.6±0.7分钟，无显著性差异）。女性受试者在运动期间心率较高，而男性受试者在运动峰值时的收缩压较高。3. 男性和女性受试者的血浆NE、E、ANP和ATII反应相当，但男性受试者在静息和运动期间的PRA以及静息时的ALD显著更高。4. 男性和女性受试者对次极量运动的心脏反应不同，但除男性受试者在静息和运动期间的PRA较高以及静息时的血浆ALD较高外，两组之间的神经激素反应相当。