在家蝇（Musca domestica）中，苯巴比妥对CYP6D1的诱导作用是由2号常染色体上的一个反式作用因子引起的。

Phenobarbital induction of CYP6D1 is due to a trans acting factor on autosome 2 in house flies, Musca domestica.

作者信息

Liu N, Scott J G

机构信息

Department of Entomology, Cornell University, Ithaca, New York 14853-0901, USA.

出版信息

Insect Mol Biol. 1997 Feb;6(1):77-81. doi: 10.1046/j.1365-2583.1997.00160.x.

DOI:10.1046/j.1365-2583.1997.00160.x

PMID:9013258

Abstract

To improve our understanding of phenobarbital (PB) mediated induction of CYP6D1 we examined the genetic linkage of PB induction using PB responsive (aabys) and non-responsive (LPR) strains of house flies. PB induction was linked to autosome 2, indicating that CYP6D1 is trans regulated by this PB inducible element. Our results are discussed relative to a previous hypothesis that the same regulatory genes are responsible for both induction and monooxygenase-mediated insecticide resistance.

摘要

为了增进我们对苯巴比妥（PB）介导的CYP6D1诱导作用的理解，我们使用家蝇的PB反应型（aabys）和无反应型（LPR）品系研究了PB诱导的遗传连锁。PB诱导与2号常染色体相关联，这表明CYP6D1受此PB诱导元件的反式调控。我们结合之前的一个假设对结果进行了讨论，该假设认为相同的调控基因负责诱导作用和单加氧酶介导的杀虫剂抗性。