Ben-Chetrit A, Senoz S, Greenblatt E M
Department of Obstetrics and Gynecology, Toronto Hospital, Ontario, Canada.
J Assist Reprod Genet. 1997 Jan;14(1):26-31. doi: 10.1007/BF02765748.
Our aim was to assess the effect of the day of ovum retrieval on outcome in an IVF program scheduled for weekday-only ovum retrievals.
This was a retrospective study of patients who underwent transvaginal ultrasound-guided ovum retrieval (TVUS-OR) in an IVF program from August 10, 1992, to April 30, 1993.
A university-based tertiary referral hospital center was the setting.
All patients (n = 501) who underwent TVUS-OR were divided into three groups: (1) patients who underwent TVUS-OR on Monday; (2) patients who underwent retrieval on Tuesday, Wednesday, or Thursday; and (3) patients who underwent retrieval on Friday. All patients were induced by the same controlled ovarian hyperstimulation protocol, which consisted of a GnRH analogue "flare-up" followed by parenteral menotropins, after a scheduled oral contraceptive-induced menses. Patients and cycle characteristics in the three groups were compared and clinical outcome was evaluated.
The similarity of patients and cycle characteristics confirmed the uniformity of the three groups. No difference was found in any of the clinical outcomes. However, in the first half of the program, we revealed a trend in which patients at high risk for ovarian hyperstimulation syndrome, requiring freezing all embryos and not allowing transfer during the treatment cycle, occurred more commonly in women whose retrieval occurred on Monday. This trend disappeared in the second half of the analysis.
In an in vitro fertilization program in which ovum retrievals occurred only on weekdays, no significant difference in outcome was found in patients undergoing ovum retrieval on Monday or Friday versus midweek. In addition to significant savings by eliminating weekend retrievals, IVF outcome is not compromised.
我们的目的是评估在仅安排工作日取卵的体外受精（IVF）程序中，取卵日对结局的影响。
这是一项对1992年8月10日至1993年4月30日在一个IVF程序中接受经阴道超声引导取卵（TVUS - OR）的患者的回顾性研究。
以一所大学为基础的三级转诊医院中心为研究地点。
所有接受TVUS - OR的患者（n = 501）被分为三组：（1）周一接受TVUS - OR的患者；（2）周二、周三或周四接受取卵的患者；（3）周五接受取卵的患者。所有患者均采用相同的控制性卵巢过度刺激方案进行诱导，该方案包括在口服避孕药诱导的预定月经后，先使用促性腺激素释放激素（GnRH）类似物“激发”，随后使用胃肠外促性腺激素。比较三组患者及周期特征，并评估临床结局。
患者及周期特征的相似性证实了三组的一致性。在任何临床结局方面均未发现差异。然而，在该程序的前半部分中，我们发现一种趋势，即卵巢过度刺激综合征高危患者（需要冷冻所有胚胎且在治疗周期内不允许移植）在周一取卵的女性中更常见。在分析的后半部分，这种趋势消失了。
在一个仅在工作日进行取卵的体外受精程序中，周一或周五取卵的患者与周中取卵的患者相比，结局无显著差异。除了通过取消周末取卵显著节省成本外，IVF结局也不受影响。
