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S(+)-布洛芬（右旋布洛芬）——极好的耐受性并不需要与较差的临床疗效相结合。

S(+)-ibuprofen (dexibuprofen)--Excellent tolerance has not to be combined with poor clinical efficacy.

机构信息

Gebro Broschek GmbH, A-6391, Fieberbrunn.

出版信息

Inflammopharmacology. 1998;6(1):75-9. doi: 10.1007/s10787-998-0008-2.

DOI:10.1007/s10787-998-0008-2
PMID:17638129
Abstract

S(+)-ibuprofen (dexibuprofen) is an NSAID offering a lot of advantages in the treatment of rheumatism and pain. A randomized double-blind, parallel group study in 110 patients showed equivalence in efficacy of 900 mg dexibuprofen (Seractil 300 mg, Gebro Fieberbrunn, Austria) vs. 150 mg diclofenac sodium. Regarding tolerance there was a trend to superiority of dexibuprofen. Therefore dexibuprofen can be characterized as an effective and very tolerable drug against inflammation and pain.

摘要

（+）-布洛芬（右旋布洛芬）是一种 NSAID，在治疗风湿病和疼痛方面具有许多优势。一项纳入 110 例患者的随机、双盲、平行分组研究显示，900mg 右旋布洛芬（Seractil 300mg，Gebro Fieberbrunn，奥地利）与 150mg 双氯芬酸钠的疗效相当。关于耐受性，右旋布洛芬有优势的趋势。因此，右旋布洛芬可以被描述为一种有效且非常耐受的抗炎和止痛药物。

相似文献

1
S(+)-ibuprofen (dexibuprofen)--Excellent tolerance has not to be combined with poor clinical efficacy.S(+)-布洛芬（右旋布洛芬）——极好的耐受性并不需要与较差的临床疗效相结合。
Inflammopharmacology. 1998;6(1):75-9. doi: 10.1007/s10787-998-0008-2.
2
[Double-blind comparative study of the effectiveness and tolerance of 900 mg dexibuprofen and 150 mg diclofenac sodium in patients with painful gonarthrosis].
Wien Klin Wochenschr. 1997 Jan 31;109(2):53-9.
3
Evaluation of the efficacy and dose-response relationship of dexibuprofen (S(+)-ibuprofen) in patients with osteoarthritis of the hip and comparison with racemic ibuprofen using the WOMAC osteoarthritis index.使用WOMAC骨关节炎指数评估右旋布洛芬（S(+)-布洛芬）对髋骨关节炎患者的疗效及剂量反应关系，并与消旋布洛芬进行比较。
Int J Clin Pharmacol Ther. 2000 Jan;38(1):15-24. doi: 10.5414/cpp38015.
4
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Clin Rheumatol. 2001 Nov;20 Suppl 1:S22-9. doi: 10.1007/BF03342664.
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Clin Rheumatol. 2001 Nov;20 Suppl 1:S15-21. doi: 10.1007/BF03342663.
6
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本文引用的文献

1
[Double-blind comparative study of the effectiveness and tolerance of 900 mg dexibuprofen and 150 mg diclofenac sodium in patients with painful gonarthrosis].
Wien Klin Wochenschr. 1997 Jan 31;109(2):53-9.
2
Nonsteroidal antiinflammatory drug modulation of behavioral responses to intrathecal N-methyl-D-aspartate, but not to substance P and amino-methyl-isoxazole-propionic acid in the rat.非甾体抗炎药对大鼠鞘内注射N-甲基-D-天冬氨酸所引起行为反应的调节作用，但对P物质和氨基甲基异恶唑丙酸所引起的行为反应无调节作用。
J Clin Pharmacol. 1996 Dec;36(12 Suppl):20S-26S.
3
Pharmacodynamics and pharmacokinetics of the profens: enantioselectivity, clinical implications, and special reference to S(+)-ibuprofen.丙酸类药物的药效学和药代动力学：对映体选择性、临床意义及对S(+)-布洛芬的特别参考
J Clin Pharmacol. 1996 Dec;36(12 Suppl):7S-15S.
4
Physical aspects of dexibuprofen and racemic ibuprofen.右旋布洛芬和消旋布洛芬的物理特性。
J Clin Pharmacol. 1996 Dec;36(12 Suppl):3S-6S.
5
Understanding the chiral pharmacology of nonsteroidal antiinflammatory drugs in the aryl propionic acid class: S(+) ibuprofen. Overview of the symposium "update on S(+) ibuprofen" (Going/Kitzbuehl, Austria, February 2-4, 1996).
J Clin Pharmacol. 1996 Dec;36(12 Suppl):1S-2S.
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Meloxicam in osteoarthritis: a 6-month, double-blind comparison with diclofenac sodium.美洛昔康治疗骨关节炎：与双氯芬酸钠进行的为期6个月的双盲对照研究。
Br J Rheumatol. 1996 Apr;35 Suppl 1:39-43. doi: 10.1093/rheumatology/35.suppl_1.39.
7
[Determination of serum pepsinogen I and II for assessment of gastroduodenal tolerance of S(+) ibuprofen].[测定血清胃蛋白酶原I和II以评估S(+)布洛芬对胃十二指肠的耐受性]
Wien Klin Wochenschr. 1994;106(7):208-11.
8
Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs.手性非甾体抗炎药的对映体选择性药效学和药代动力学
Eur J Clin Pharmacol. 1992;42(3):237-56. doi: 10.1007/BF00266343.