Pugh C R, Fleshner M, Rudy J W
Department of Psychology, University of Colorado, Boulder 80309, USA.
Neurobiol Learn Mem. 1997 Jan;67(1):75-9. doi: 10.1006/nlme.1996.3741.
There is evidence that glucocorticoids may play a role in learning and memory. To further explore this possibility, we examined the effect of the Type II glucocorticoid antagonists on contextual fear conditioning. This conditioning task is dependent on the hippocampal formation, a brain structure known to be rich in glucocorticoid receptors. Rats systemically injected with a Type II antagonist either 1 h prior to conditioning (RU 38486 and RU 40555) or immediately after conditioning displayed less contextual fear conditioning than rats injected with vehicle. Although RU impaired contextual fear conditioning, it had no effect on auditory fear conditioning. These data are consistent with other reports that contextual fear conditioning and auditory-cue fear conditioning depend on different processes and with the hypothesis that glucocorticoid activity contributes to the processes involved in the consolidation of some forms of memory.
有证据表明糖皮质激素可能在学习和记忆中发挥作用。为了进一步探究这种可能性，我们研究了II型糖皮质激素拮抗剂对情境恐惧条件反射的影响。这种条件反射任务依赖于海马结构，已知该脑结构富含糖皮质激素受体。在条件反射前1小时全身注射II型拮抗剂（RU 38486和RU 40555）的大鼠或在条件反射后立即注射的大鼠，与注射赋形剂的大鼠相比，表现出较少的情境恐惧条件反射。虽然RU损害了情境恐惧条件反射，但对听觉恐惧条件反射没有影响。这些数据与其他报告一致，即情境恐惧条件反射和听觉线索恐惧条件反射依赖于不同的过程，并且与糖皮质激素活性有助于某些形式记忆巩固所涉及过程的假设一致。
