Amos L A, Hirose K
Medical Research Council Laboratory of Molecular Biology, Medical Research Council, Centre Hills Road, Cambridge CB2 2QH, UK.
Curr Opin Cell Biol. 1997 Feb;9(1):4-11. doi: 10.1016/s0955-0674(97)80145-7.
New images, calculated from electron micrographs, show the three-dimensional structures of microtubules and tubulin sheets decorated stoichiometrically with globular motor protein domains (heads). Single heads of kinesin and ncd, the kinesin-related protein that moves in the reverse direction to kinesin, bind in the same way to the same site on tubulin. Dimeric kinesin and dimeric ncd show an interesting difference in the positions of their second heads.
根据电子显微镜图像计算得出的新图像，展示了微管和微管蛋白片层的三维结构，这些结构以化学计量的方式被球状运动蛋白结构域（头部）修饰。驱动蛋白和ncd（一种与驱动蛋白运动方向相反的驱动蛋白相关蛋白）的单个头部，以相同的方式结合到微管蛋白上的相同位点。二聚体驱动蛋白和二聚体ncd在其第二个头部的位置上显示出有趣的差异。
