Welch M D, Mallavarapu A, Rosenblatt J, Mitchison T J
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-0450, USA.
Curr Opin Cell Biol. 1997 Feb;9(1):54-61. doi: 10.1016/s0955-0674(97)80152-4.
Actin dynamics in lamellipodia are driven by continuous cycles of actin polymerization, retrograde flow, and depolymerization. In the past year, advances have been made in identifying signaling pathways that regulate actin-filament uncapping and polymerization, in determining the role of myosin motor proteins in retrograde flow, and in evaluating the role of severing proteins in actin depolymerization. Both Listeria monocytogenes and Saccharomyces cerevisiae have emerged as powerful model organisms for studying actin dynamics in cells.
片状伪足中的肌动蛋白动力学由肌动蛋白聚合、逆向流动和解聚的连续循环驱动。在过去的一年里，在确定调节肌动蛋白丝去封端和聚合的信号通路、确定肌球蛋白运动蛋白在逆向流动中的作用以及评估切割蛋白在肌动蛋白解聚中的作用方面都取得了进展。单核细胞增生李斯特菌和酿酒酵母都已成为研究细胞中肌动蛋白动力学的强大模式生物。
