在分离出的牛蛙坐骨神经中，C纤维的河豚毒素抗性钠峰至少有两种亚型。
Tetrodotoxin-resistant Na+ spikes of C fibers have at least two subtypes in the isolated bullfrog sciatic nerve.
作者信息
Kobayashi J, Ohta M, Terada Y
机构信息
Department of Prosthetic Dentistry I, Faculty of Dentistry, Kyushu University, Fukuoka, Japan.
出版信息
Neurosci Lett. 1996 Dec 27;221(1):9-12. doi: 10.1016/s0304-3940(96)13269-9.
The C fiber compound action potentials (C-CAPs) were studied for their properties with the vaseline gap method from the isolated bullfrog sciatic nerve. Two components (the fast and the slow C-CAPs) were found to be Na+ dependent and tetrodotoxin-resistant. The conduction velocities of the fast and the slow C-CAPs were 0.61 +/- 0.06 m/s (n = 13) and 0.42 +/- 0.05 m/s (n = 8), respectively; their time constants were 11.4 +/- 1.7 m/s and 16.3 +/- 1/7 ms, respectively, with both parameters being significantly different at P < 0.01. The slow C-CAP had about 1.3 times higher threshold than that of the fast C-CAP, with a significant difference (P < 0.01). They showed differential sensitivity to lidocaine and Cd2+. Capsaicin reduced the amplitudes of both fast and slow C-CAPs, but not abolished. These findings indicate that C fibers have at least two subtypes with different properties.
采用凡士林间隙法，从分离的牛蛙坐骨神经研究了C纤维复合动作电位（C-CAPs）的特性。发现两个成分（快速和慢速C-CAPs）依赖于Na+且对河豚毒素具有抗性。快速和慢速C-CAPs的传导速度分别为0.61±0.06 m/s（n = 13）和0.42±0.05 m/s（n = 8）；它们的时间常数分别为11.4±1.7 ms和16.3±1.7 ms，两个参数在P<0.01时均有显著差异。慢速C-CAP的阈值比快速C-CAP高约1.3倍，差异显著（P<0.01）。它们对利多卡因和Cd2+表现出不同的敏感性。辣椒素降低了快速和慢速C-CAPs的幅度，但并未消除。这些发现表明C纤维至少有两种具有不同特性的亚型。
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