Shin H C, Park H J, Raymond S A, Strichartz G R
Department of Physiology, College of Medicine, Hallym University, Chunchon, South Korea.
Neurosci Lett. 1994 Jun 6;174(1):14-6. doi: 10.1016/0304-3940(94)90107-4.
Compound action potentials (CAPs) of A- and C-fibers were recorded from isolated sciatic nerves of the rat to determine whether tonic block of impulse conduction induced by lidocaine was affected by low doses of capsaicin. Capsaicin alone (50 microM) did not change the CAPs of either A- or C-fibers. Although the lower concentrations of capsaicin (5-30 microM) caused no change of the tonic blocking action of lidocaine, 30 min of 50 microM capsaicin administration did induce a significant potentiation of tonic block. Capsaicin's potentiating effects were partially reversed after 30 min of wash. These results suggest that capsaicin may be a useful agent for the potentiation of impulse blockade by lidocaine.
从大鼠分离的坐骨神经记录A纤维和C纤维的复合动作电位（CAPs），以确定低剂量辣椒素是否会影响利多卡因诱导的冲动传导的强直阻滞。单独使用辣椒素（50微摩尔）不会改变A纤维或C纤维的CAPs。虽然较低浓度的辣椒素（5 - 30微摩尔）不会改变利多卡因的强直阻滞作用，但给予50微摩尔辣椒素30分钟确实会显著增强强直阻滞。冲洗30分钟后，辣椒素的增强作用部分逆转。这些结果表明，辣椒素可能是增强利多卡因冲动阻滞作用的有用药物。
