Cuevas P, Reimers D, Giménez-Gallego G
Servicio de Histología, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Neurosci Lett. 1996 Dec 27;221(1):25-8. doi: 10.1016/s0304-3940(96)13277-8.
The immunocytochemical localization of basic fibroblast growth factor (bFGF) was studied in subcommissural organ (SCO) of aged-matched normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SH) rats at 10, 14 and 18 months of age using a polyclonal antibody against bFGF. The bFGF-like immunoreactivity (bFGF-ir) was observed in SCO ependymal cells of young and old normotensive rats. However, a progressive loss of bFGF-immunopositive ependymal SCO cells was observed with age in SH rats (27.24, 57.5 and 96.9% in 10, 14 and 18 months old respectively) compared with aged-matched WKY normotensive rats. Considering the potential role of the SCO in sleep regulation and sodium homeostasis, which are altered in essential hypertension, these data show a new neuroendocrine anomaly to be added to the many others previously observed in this rat strain, when they develop hypertension as they get old.
使用抗碱性成纤维细胞生长因子（bFGF）的多克隆抗体，研究了10、14和18月龄年龄匹配的正常血压Wistar-Kyoto（WKY）大鼠和自发性高血压（SH）大鼠的室管膜下器官（SCO）中碱性成纤维细胞生长因子（bFGF）的免疫细胞化学定位。在年轻和老年正常血压大鼠的SCO室管膜细胞中观察到bFGF样免疫反应性（bFGF-ir）。然而，与年龄匹配的WKY正常血压大鼠相比，SH大鼠中随着年龄增长，bFGF免疫阳性的SCO室管膜细胞逐渐减少（10、14和18月龄分别为27.24%、57.5%和96.9%）。考虑到SCO在睡眠调节和钠稳态中的潜在作用，而这些在原发性高血压中会发生改变，这些数据表明，当这种大鼠品系随着年龄增长出现高血压时，在先前观察到的许多其他异常之外，又出现了一种新的神经内分泌异常。
