Cuevas P, Gimenez-Gallego G, Martinez-Murillo R, Carceller F
Servicio de Histología, Hospital Ramón y Cajal, Madrid, Spain.
Acta Anat (Basel). 1991;141(4):307-10. doi: 10.1159/000147140.
The presence of basic fibroblast growth factor (bFGF) in the third and the lateral ventricular ependyma of the rat has been investigated under the light microscope using a polyclonal antibody against bFGF, through the unlabelled peroxidase-antiperoxidase procedure; bFGF-immunoreactivity (bFGF-IR) is observed in the entire ependymal cell layer of ventricles. Also ependymal tanycytes within the inferior portion of the wall and floor of the third ventricle show bFGF-IR. Tanycytic processes are in close contact with hypothalamic capillaries. The present study strongly suggests that brain ependymal bFGF plays unidentified roles unrelated to its angiogenic or mitogenic capacities.
利用抗碱性成纤维细胞生长因子（bFGF）的多克隆抗体，通过未标记过氧化物酶-抗过氧化物酶方法，在光学显微镜下研究了大鼠第三脑室和侧脑室室管膜中bFGF的存在情况；在脑室的整个室管膜细胞层中观察到bFGF免疫反应性（bFGF-IR）。第三脑室壁和底部下部的室管膜伸长细胞也显示出bFGF-IR。伸长细胞的突起与下丘脑毛细血管紧密接触。本研究强烈表明，脑室内管膜bFGF发挥着与其血管生成或促有丝分裂能力无关的未知作用。
