在急性下肢缺血时，前列环素和血栓素A2的合成增加。

Prostacyclin and thromboxane A2 synthesis are increased in acute lower limb ischaemia.

作者信息

Rossi P, Kuukasjärvi P, Riutta A, Salenius J P, Tarkka M, Mucha I, Kerttula T, Alanko J

机构信息

Department of Surgery, Tampere University Hospital, Tampere, Finland.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 1996 Dec;55(6):433-6. doi: 10.1016/s0952-3278(96)90127-1.

DOI:10.1016/s0952-3278(96)90127-1

PMID:9014222

Abstract

Prostacyclin (PGI2) and thromboxane A2 (TXA2) play an important role in the pathophysiology of various cardiovascular diseases. The balance between PGI2 and TXA2 regulates the interaction between platelets and the vessel wall in vivo. In this study we measured PGI2 and TXA2 synthesis by analysing their urinary index metabolites 2,3-dinor-6-keto-PGF1 alpha and 11-dehydro-TXB2, respectively, in acute (10 patients) and chronic (10 patients) lower limb ischaemia. Both PGI2 and TXA2 synthesis were increased about two-fold in patients with acute lower limb ischaemia compared to chronic lower limb ischaemia. However, the PGI2/TXA2 ratio was more or less the same in acute and chronic lower limb ischaemia. In patients with acute lower limb ischaemia caused by thrombotic occlusion, PGI2 and TXA2 formation were about two times higher than in patients with acute lower limb ischaemia caused by embolic occlusion. Elevation of PGI2 and TXA2 synthesis in acute lower limb ischaemia may reflect increased platelet-vascular wall interactions without changing the PGI2/TXA2 ratio.

摘要

前列环素（PGI2）和血栓素A2（TXA2）在多种心血管疾病的病理生理学中起重要作用。PGI2和TXA2之间的平衡在体内调节血小板与血管壁之间的相互作用。在本研究中，我们通过分别分析急性（10例患者）和慢性（10例患者）下肢缺血患者尿液中PGI2和TXA2的指标代谢物2,3-二去甲-6-酮-PGF1α和11-脱氢-TXB2，来测定PGI2和TXA2的合成。与慢性下肢缺血患者相比，急性下肢缺血患者的PGI2和TXA2合成均增加了约两倍。然而，急性和慢性下肢缺血患者的PGI2/TXA2比值大致相同。在由血栓闭塞引起的急性下肢缺血患者中，PGI2和TXA2的生成量比由栓子闭塞引起的急性下肢缺血患者高约两倍。急性下肢缺血时PGI2和TXA2合成的升高可能反映了血小板-血管壁相互作用的增加，而PGI2/TXA2比值未发生改变。