Tachibana H
Fifth Department of Internal Medicine, Hyogo College of Medicine.
Nihon Rinsho. 1997 Jan;55(1):189-94.
The visual event-related potentials(ERPs) in Parkinson's disease(PD) are reviewed. In patients with demented PD, the task-relevant P3(P3b, target P3) latency is significantly prolonged compared with the control, while patients with nondemented PD show inconsistent results, probably due to the difference in experimental procedure or antiparkinsonian medication. The task-irrelevant P3(P3a, nontarget P3) latency under conditions of passive attention is not prolonged in PD regardless of the presence of dementia. The results of P3 amplitudes remain controversial. The N2 latency is delayed compared to the control during the semantic discrimination task, although there is no difference in NA latency. The attenuation in the CNV(contingent negative variation) amplitude is found in PD patients, probably due to the impairment, either in maintaining their attention or preparing the response.
本文综述了帕金森病（PD）患者的视觉事件相关电位（ERP）。与对照组相比，痴呆型PD患者中与任务相关的P3（P3b，目标P3）潜伏期显著延长，而非痴呆型PD患者的结果则不一致，这可能是由于实验程序或抗帕金森药物的差异所致。在被动注意条件下，无论是否存在痴呆，PD患者中与任务无关的P3（P3a，非目标P3）潜伏期均未延长。P3波幅的结果仍存在争议。在语义辨别任务中，与对照组相比，N2潜伏期延迟，尽管NA潜伏期没有差异。在PD患者中发现关联性负变（CNV）波幅衰减，这可能是由于他们在维持注意力或准备反应方面存在障碍。
