Hansch E C, Syndulko K, Cohen S N, Goldberg Z I, Potvin A R, Tourtellotte W W
Ann Neurol. 1982 Jun;11(6):599-607. doi: 10.1002/ana.410110608.
Auditory event-related potentials (ERP) elicited in a target detection stimulus paradigm and pattern-shift visual ERPs were studied in 20 male patients with idiopathic Parkinson disease (PD) and 20 age-matched normal controls. Patients showed significantly increased latencies for both the P200 and P300 components of the auditory ERP. Patients and controls showed no significant differences in latency of the visual ERP but patients showed significantly decreased amplitude. Only one of five neuropsychological measures, the Symbol Digit Modalities test (SDMT), showed a significant negative correlation with P300 latency. The significant association between the two measures that showed impairments in the PD patients (P300 latency and SDMT scores) suggested that these measures reflect a common, disrupted aspect of cognitive function in PD.
在目标检测刺激范式中诱发的听觉事件相关电位（ERP）以及模式翻转视觉ERP，在20名特发性帕金森病（PD）男性患者和20名年龄匹配的正常对照者中进行了研究。患者的听觉ERP的P200和P300成分的潜伏期显著延长。患者和对照者的视觉ERP潜伏期无显著差异，但患者的波幅显著降低。五项神经心理学测量中只有一项，即符号数字模态测验（SDMT），与P300潜伏期呈显著负相关。在PD患者中表现出损伤的两项测量指标（P300潜伏期和SDMT分数）之间的显著关联表明，这些测量指标反映了PD患者认知功能中一个共同的、受到干扰的方面。
