Silveri Marisa M, Pollack Mark H, Diaz Claudia I, Nassar Leanne E, Mendelson Jack H, Yurgelun-Todd Deborah A, Renshaw Perry F, Kaufman Marc J
Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
Psychiatry Res. 2004 Sep 15;131(3):217-26. doi: 10.1016/j.pscychresns.2004.05.003.
Cerebral bioenergetic and phospholipid abnormalities have been reported in heroin-dependent subjects. The goal of the present study was to characterize the neurochemical profile of subjects voluntarily enrolled in a methadone maintenance (MM) treatment program to overcome their heroin addiction. Participants included 43 heroin-dependent subjects during their first month of MM and 15 age-matched healthy individuals. Phosphorus magnetic resonance spectroscopy ((31)P MRS) and transverse relaxation times (T2-RT), which can reflect steady state cerebral perfusion and metabolism, were acquired at 1.5 T from an axial slice prescribed through the orbitofrontal and occipital cortices, including basal ganglia and frontal cortex. MM subjects exhibited reduced phosphocreatine (PCr) levels (-15.3%), elevated phosphodiesters (+ 12.9%, PDE) and significantly longer T2-RT ((+) 2.1%) compared with healthy comparison subjects. When MM subjects were stratified into subgroups based on treatment duration, we found a treatment duration effect on metabolite values but not T2-RT; reduced PCr was observed only after 8+ days of MM, and phosphomonoesters (PME) were elevated in the 15-28 day MM group. Taken together, these cross-sectional data suggest that the first month of MM treatment may be associated with altered cerebral bioenergetics and phospholipid metabolite levels.
据报道，海洛因依赖者存在脑生物能量和磷脂异常。本研究的目的是描述自愿参加美沙酮维持（MM）治疗项目以克服海洛因成瘾的受试者的神经化学特征。参与者包括43名处于MM治疗第一个月的海洛因依赖者和15名年龄匹配的健康个体。在1.5T磁场下，从一个穿过眶额皮质和枕叶皮质（包括基底神经节和额叶皮质）的轴向切片获取可反映脑稳态灌注和代谢的磷磁共振波谱（(31)P MRS）和横向弛豫时间（T2-RT）。与健康对照受试者相比，MM受试者的磷酸肌酸（PCr）水平降低（-15.3%），磷酸二酯升高（+12.9%，PDE），T2-RT显著延长（(+)2.1%）。当根据治疗持续时间将MM受试者分层为亚组时，我们发现治疗持续时间对代谢物值有影响，但对T2-RT没有影响；仅在MM治疗8天以上后观察到PCr降低，在MM治疗15 - 28天组中磷酸单酯（PME）升高。综上所述，这些横断面数据表明，MM治疗的第一个月可能与脑生物能量和磷脂代谢物水平的改变有关。
