Itoh S, Satake H, Katoh T, Isomura T, Ikeda M, Ishigaki T
Department of Radiology, Nagoya Memorial Hospital.
Nihon Igaku Hoshasen Gakkai Zasshi. 1996 Dec;56(14):1039-44.
The detectability of various abnormal findings in helical screening CT(HSCT) with low-dose and single-breath-hold scanning of the lung was examined using conventional CT as a gold standard. In 75 patients, HSCT was obtained with scanning parameters of 120kVp, 50 mA, 10 mm-collimation. 20 mm/second and 1 sec/rotation. Conventional CT was obtained with 150 mA and 10 mm-slice contiguous scanning HSCT depicted 141 of 159 focal lesions in nodules and masses (65 of 69 lesions more than 5mm in size), 44 of 47 in infiltrative lesions, 11 of 11 in reticular lesions and 23 of 39 in bullae and blebs. There were only 3 false positive lesions in nodule and mass. Sensitivity, specificity and accuracy of HSCT for diffuse lesions were 100% (11/11), 95% (61/64) and 96% (72/75) for fibrotic change and 75% (9/12), 100% (63/63) and 96% (72/75) for emphysematous change, respectively. Since the detectability of HSCT was good for abnormal findings, showing increased attenuation in comparison with the lung parenchyma, it was considered to be a promising method for lung-cancer screening.
以传统CT作为金标准，对螺旋扫描CT（HSCT）低剂量单屏气肺部扫描中各种异常表现的可检测性进行了研究。75例患者接受了HSCT扫描，扫描参数为120kVp、50mA、10mm准直、20mm/秒和1秒/旋转。传统CT扫描参数为150mA、10mm层厚连续扫描。HSCT显示了159个结节和肿块中的141个局灶性病变（69个大小超过5mm的病变中的65个）、47个浸润性病变中的44个、11个网状病变中的11个以及39个肺大泡和肺小泡中的23个。结节和肿块中仅有3例假阳性病变。HSCT对弥漫性病变的敏感性、特异性和准确性分别为：纤维化改变为100%（11/11）、95%（61/64）和96%（72/75）；肺气肿改变为75%（9/12）、100%（63/63）和96%（72/75）。由于HSCT对与肺实质相比呈密度增高的异常表现具有良好的可检测性，因此被认为是一种有前景的肺癌筛查方法。
