Itoh S, Ikeda M, Isomura T, Endo T, Yamakawa K, Itoh K, Naganawa S, Maruyama K, Ishigaki T
Department of Radiology, Nagoya Memorial Hospital, Japan.
Radiat Med. 1998 Mar-Apr;16(2):75-83.
To investigate the usefulness of helical CT with low-dose and single-breath-hold scanning for lung cancer screening.
Twenty-four helical CT scans of the lung were performed using various parameters in 10 healthy volunteers. The effects of tube current and pitch were evaluated by assessment of image quality and detection of simulated nodules. Screening helical CT was performed at 120 kVp, 50 mA, 1 sec/rotation, 10 mm collimation, and a pitch of 2.0 in 110 patients. The ability of this method to detect nodules and masses, focal parenchymal opacities, and diffuse fibrotic changes was evaluated using conventional CT as the gold standard.
A reduction in tube current to 50 mA did not significantly change the assessment of image quality or detection of simulated nodules. Although these factors were degraded by increasing the pitch, there was no significant difference between 1.5 and 2.0. Screening helical CT permitted the entire lung to be scanned with ease during a single-breath-hold in all patients. This method detected 177 of 196 nodules and masses (87 of 91 lesions greater than 5 mm in diameter), 54 of 57 focal parenchymal opacities, and 15 of 15 cases with fibrotic changes.
Screening helical CT with low-dose and single-breath-hold scanning shows promise for lung cancer screening.
探讨低剂量单屏气螺旋CT扫描在肺癌筛查中的应用价值。
对10名健康志愿者进行了24次肺部螺旋CT扫描，采用了不同的参数。通过图像质量评估和模拟结节检测来评估管电流和螺距的影响。对110例患者进行了筛查螺旋CT扫描，扫描条件为120 kVp、50 mA、1秒/旋转、10 mm准直和2.0的螺距。以传统CT作为金标准，评估该方法检测结节和肿块、局灶性实质密度增高影以及弥漫性纤维化改变的能力。
将管电流降低至50 mA对图像质量评估或模拟结节检测无显著影响。尽管随着螺距增加这些因素有所下降，但1.5和2.0之间无显著差异。筛查螺旋CT能够在所有患者的一次屏气过程中轻松完成全肺扫描。该方法检测出了196个结节和肿块中的177个（直径大于5 mm的91个病灶中的87个）、57个局灶性实质密度增高影中的54个以及15例纤维化改变中的15例。
低剂量单屏气螺旋CT扫描在肺癌筛查中显示出应用前景。
