γ辐射对小鼠胎儿造血作用的影响。
Effect of gamma radiation on fetal haemopoiesis of mouse.
作者信息
Hossain M, Devi P U, Bisht K S
机构信息
Department of Radiobiology, Kasturba Medical College, Manipal, India.
出版信息
Indian J Exp Biol. 1996 Sep;34(9):880-2.
Effect of a single acute exposure to gamma-rays during the late fetal period on the fetal haemopoietic tissue of mouse was studied. Pregnant Swiss albino mice were exposed to 1 Gy of gamma-rays on day 17 post coitus (late fetal period) and 24 hr after exposure the fetuses were observed for changes in the liver weight, cytogenetic damage in liver cells by micronucleus (MN) induction and stem cell survival by spleen colony (CFU-S) assay. Irradiation resulted in a significant (P < 0.01) decrease in fetal liver weight. A significant (P < 0.001) increase in MN count was observed after exposure, while CFU-S displayed a significant (P < 0.001) reduction in the cell survival as compared to the sham-treated control. These results demonstrate the high susceptibility of mouse fetal haemopoietic system to radiation.
研究了孕期晚期单次急性暴露于γ射线对小鼠胎儿造血组织的影响。将怀孕的瑞士白化小鼠在交配后第17天（孕期晚期）暴露于1 Gy的γ射线下，暴露后24小时观察胎儿肝脏重量的变化、通过微核（MN）诱导检测肝细胞的细胞遗传学损伤以及通过脾集落（CFU-S）试验检测干细胞存活情况。照射导致胎儿肝脏重量显著（P < 0.01）下降。暴露后观察到微核计数显著（P < 0.001）增加，而与假处理对照组相比，CFU-S显示细胞存活率显著（P < 0.001）降低。这些结果表明小鼠胎儿造血系统对辐射高度敏感。
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